Glycomet 500 MG Tablet: Uses, Side Effects, Composition & Dosages

Glycomet 500 MG Tablet: Uses, Side Effects, Composition & Dosages post thumbnail image

Glycomet 500 MG Tablet belongs to a category of anti-diabetic drugs. It is usually prescribed for the treatment of diabetes mellitus (Type 2 Diabetes). Glycomet 500 controls diabetes by lowering the sugar level in the blood and also increasing the sensitivity of the body towards insulin.

Uses:Type II Diabetes, Polycystic Ovarian Syndrome
Side-effects:Stomach Discomfort, Taste Disturbance, Vomiting, Weakness, Hypoglycemia, Headache
Precautions:Patients suffering from liver and kidney-related ailments

While administering Glycomet 500, patients are advised to maintain a strict diet and exercise routine to get the best possible results. This tablet may also be prescribed to minimize diabetes-associated risks such as kidney damage, heart attack, blindness, and stroke. Glycomet 500 MG tablet is manufactured by Usv Ltd.

Uses and Benefits of Glycomet 500:

  • Medicine may be used to lower the high blood sugar level in patients suffering from Type 2 Diabetes.
  • It may be used with sulfonylureas to reduce the total cholesterol level in the body.
  • The tablet may be prescribed for the treatment of conditions such as obesity, cardiovascular diseases, hypertension, and PCOS.

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Side Effects of Glycomet 500:

Some of the side-effects associated with the consumption of Glycomet 500 MG Tablets include –

  • Diarrhea
  • Flatulence
  • Stomach Pain
  • Taste Disorders
  • Vomiting
  • Hypoglycemia
  • Headache
  • Indigestion
  • Loss Of Appetite
  • Nausea
  • Lactic Acidosis
  • Chest Discomfort
  • Runny Nose
  • Swollen joints
  • Hives
  • Pruritus

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Common Dosage of Glycomet 500:

A doctor may prescribe the dose based on several factors such as the age, medical history, present health condition of the patient, etc.

The generally prescribed dosage for adults

Initially, the doctor may prescribe a dose of 500 mg to be taken twice in a day or a dose of 850mg to be taken once a day with food. The maximum dose of the medicine that may be prescribed is 2550 mg per day which may be taken once a day with food.

The generally prescribed doses for children

Initially, the doctor may prescribe a dose of 500 mg to be taken once a day with food. The dose may be increased to a maximum of 2000 mg/per day.

  • Missed Dose: A missed dose should be taken as soon as the patient remembers it. In case it is time for the next scheduled dose, the missed dose can be skipped. Under no circumstances should a patient take an extra dose to make up for the missed dose.
  • Overdose: Taking more than the recommended doses of tablets may lead to Lactic Acidosis. In case, an overdose is suspected, it is suggested to visit a doctor immediately.

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Composition & Nature of Glycomet 500:

Glycomet 500 MG tablet belongs to a class of anti-diabetic drugs. The active ingredient of these tablets is metformin (500 mg). Metformin is a biguanide antihyperglycemic agent (a compound that exerts a blood glucose-lowering effect in type 2 diabetes). It lowers the production of glucose in the liver and delays sugar absorption in the intestines. Metformin also increases the patient’s sensitivity to insulin.

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Glycomet 500 MG Tablet Price in India:

QuantityCompany NameINR
10 tabletsUSV Ltd16

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How to use Glycomet 500 MG Tablet?

Medicine is effective only when taken in the right manner. Here is how one should administer Glycomet 500 MG tablets –

  • The Tablet must be administered in the exact dose and duration directed by the doctor.
  • The medicine must be swallowed and not chewed, crushed or broken.
  • It must be taken with food.

How Glycomet 500 works?

Glycomet 500 performs a number of functions that lead to the regularization of the amount of glucose in the blood. The active ingredient present in the medicine is Metformin which decreases the level of glucose in the blood by reducing the production of glucose through the process of gluconeogenesis. The medicine also decreases the intestinal absorption of glucose and improves insulin sensitivity by increasing glucose uptake and utilization.

When Glycomet 500 is prescribed?

Glycomet 500 MG tablets are usually be prescribed for the treatment of Type II Diabetes . It may also be prescribed to treat the symptoms associated with a hormonal condition known as Polycystic Ovarian Syndrome (PCOD) in females.

Warnings/Precautions – When to avoid Glycomet 500 MG Tablet –

  • The patients must inform their doctor about any medicines they are currently administering.
  • The doctor must also be informed about any medical condition the patient is suffering from.
  • Patients suffering from kidney or liver-related ailments are suggested to avoid the use of Glycomet 500 MG tablets as this medicine may lead to the buildup of lactic acid in the body.
  • It must be avoided by patients known to have an allergic reaction to any component present in the medicine.
  • Patients suffering from blood-related ailments must consult the doctor before administering this medicine as the use of Glycomet 500 Mg tablets may alter the hematologic parameters and lead to red blood cell deficiency.

Substitutes for Glycomet 500:

  • Matee 500mg Tablet manufactured by Tas Med India Pvt Ltd
  • Glyciphage Tablet manufactured by Franco-Indian Pharmaceuticals Pvt Ltd
  • Gluformin 500 Tablet manufactured by Abbott
  • Metatime 500 Tablet manufactured by Mankind Pharma Ltd
  • Okamet 500 Tablet manufactured by Cipla Ltd
  • Obimet 500mg Tablet manufactured by Corona Remedies Pvt Ltd
  • Zomet Tablet manufactured by Intas Pharmaceuticals Ltd
  • Forson 500mg Tablet manufactured by Unison Pharmaceuticals Pvt Ltd
  • Bigomet 500 Tablet manufactured by Aristo Pharmaceuticals Pvt Ltd
  • X Met 500 Tablet manufactured by Glenmark Pharmaceuticals Ltd
  • Walaphage 500 Tablet manufactured by Wallace Pharmaceuticals Pvt Ltd
  • Melmet 500 Tablet manufactured by Micro Labs Ltd
  • MR Met 500mg Tablet manufactured by Akesiss Pharma Pvt Ltd
  • Etformin 500mg Tablet manufactured by Deys Medical
  • Glybza 500 Tablet manufactured by Jubilant Life Sciences

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Glycomet 500 MG Interactions with Other Drugs:

Interaction with medicine

The medicine may interact with the following types of drugs and lead to unwanted side effects –

  • Multidrug and Toxin Extrusion Inhibitors – It may interact with multidrug and toxin extrusion inhibitors. These drugs are used for the treatment of chest pain, cancer , ulcer, and viral, fungal or bacterial infections. Consumption of tablets along with these drugs may lead to the accumulation of lactate in the body.

Example of multidrug and toxin extrusion inhibitors:-

  1. Dolutegravir
  2. Isavuconazole
  3. Trimethoprim
  4. Ranolazine
  5. Vandetanib
  6. Cimetidine
  • Calcium Channel Blockers – When Glycomet 500 tablets are taken with calcium channel blockers, the level of medicine in the blood may increase due to delayed absorption. This increase may result in drug toxicity.

Example of calcium channel blocker –

  1. Nifedipine
  • Diuretics – Diuretics may interact with Glycomet 500 and increase the chances of drug toxicity due to improper functioning of the kidneys. Monitoring of the functioning of the kidney and regular glucose tests may be prescribed to normalize the dose of Glycomet 500 MG tablets.

Example of Diuretics

  1. Furosemide
  • Organic Cationic Transporter Inducers-1 – Administering this medicine with organic cation transporter-1 inducer may escalate the absorption in the stomach and intestines and alter the effect of the medicine.

Example of Organic Cationic Transporter Inducers-1

  1. Rifampicin
  • Organic Cationic Transporter Inhibitors-1 and 2 – Taking Glycomet 500 MG tablets with organic cationic transporter- 2 drugs may alter the effectiveness and removal of the medicine from the body.

Example of Organic Cationic Transporter Inhibitors-1 and 2

  1. Crizotinib
  2. Olaparib
  • Non-Steroidal Anti-Inflammatory Drugs – Use of the tablets with Non-Steroidal Anti-Inflammatory Drugs may affect the functioning of the kidneys which may further lead to the risk of lactate build-up in the body.
  • Ionated Contrast Agents – Use of iodinated contrast agents which are administered through the blood vessels may increase the risk of acid build up in the body and affect the functioning of the kidneys.
  • Carbonic Anhydrase Inhibitors – Carbonic Anhydrase Inhibitors are used for the treatment of a damaged optic nerve. Consumption of Glycomet 500 MG tablets with carbonic anhydrase inhibitors may intensify the risk of lactate accumulation in the body and thus, should be avoided unless advised by the doctor.

Examples of Carbonic Anhydrase Inhibitors are-

  1. Topiramate
  2. Zonisamide
  3. Acetazolamide
  4. Dichlorphenamide

Interaction with diseases

Vitamin B12 Deficiency – The tablet may worsen the condition of the patients suffers from a deficiency of Vitamin B12. Lactic Acidosis

Regular administration of the medicine may make the patients susceptible to developing a condition known as Lactic Acidosis. This condition is characterized by the accumulation of lactate in the blood.

Other conditions – Patients suffers from cardiovascular diseases, acute myocardial infarction, diabetic ketoacidosis, and hypersensitivity to the medicine may avoid using the medicine.

Interaction with alcohol

Consumption of alcohol while taking Glycomet 500 MG tablets may increase the risk of Lactic Acidosis in patients. Thus, it is advised to not consume alcohol while administering medicine.

Medicines that should not be taken with Glycomet 500:

Mentioned below is a list of medicines that must not be taken with Glycomet 500 –

  • Topiramate
  • Zonisamide
  • Acetazolamide
  • Dichlorphenamide
  • Crizotinib
  • Olaparib
  • Nifedipine
  • Rifampicin
  • Dolutegravir
  • Isavuconazole
  • Trimethoprim
  • Ranolazine
  • Vandetanib
  • Cimetidine

How to store it?

  • Glycomet 500 MG Tablet must be stored at room temperature away from places where it can retain moisture.
  • Caution should be exercised to keep Glycomet 500 away from the reach of pets and children.
  • Glycomet 500 MG Tablet should be kept away from direct heat and sunlight.


1) Do Glycomet 500 MG tablets cause weight loss?

Ans: Metformin present in the medicine may cause weight loss in patients suffering from conditions such as PCOS and Type 2 diabetes when combined with the right diet and exercise. However, the medicine must not be used only for the purpose of weight loss without consulting the doctor.

2) How much time does it take for Glycomet 500 MG to show its effect?

Ans: The peak effect of the drug can be observed within 1 – 3 hours of oral administration.

3) How long does the effect of Glycomet 500 MG last?

Ans: The effect of the medicine may last for approximately 4 to 8 hours.

4) Is this medicine habit forming?

Ans: No. Glycomet 500 is not habit-forming.

5) Is it safe to administer Glycomet 500 MG tablets during pregnancy?

Ans: It is not recommended for pregnant women unless deemed absolutely necessary by a doctor. However, the doctor will only prescribe the medicine if its intended benefits outweigh the associated risks.

6) Is Glycomet 500 MG safe for use by lactating mothers?

Ans: It is safe to be used by lactating mothers. However, all the risks and benefits must be discussed with the doctor before taking the Tablet.

7) Who should not take these tablets?

Ans: Patients who suffer from severe kidney impairment, metabolic acidosis, or metformin allergy are advised not to consume Glycomet 500 MG Tablet.

8) How does it work?

Ans: It works by decreasing the level of glucose in the body.

9) Is it safe to administer Glycomet 500 to children?

Ans: It should not be administered by children under the age of 10 years.

10) What happens if a patient takes more than the prescribed dose of Glycomet 500 MG?

Ans: Overdosing on Glycomet 500 MG may lead to conditions such as lactic acidosis. The symptoms of overdosing on the medicine may include muscle weakness, stomach ache, irregular heartbeat, difficulty in breathing, cold or numb sensation in the legs and arms. It is advisable to consult a doctor for remedial action in case any severe side effects are observed.

11) What will happen if I take an expired dose of Glycomet 500 MG?

Ans: Taking a single dose of an expired medicine may not exhibit severe side effects. However, expired medicine may not be effective in curing the prescribed condition. Patients are suggested to check the expiry date of the medicine before administering the medicine.

12) Can this tablet cause diarrhea?

Ans: Yes, It may cause diarrhea as a side effect at the beginning of the course. However, in most cases, diarrhea weans off by itself. Patients are advised to consult a doctor if the problem becomes severe or persists for a longer duration.

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