Combiflam Tablet | Uses, Side Effects, Dosage, Composition & Price

Combiflam is a combination medicine manufactured by Sanofi India Ltd. Combiflam belongs to category of Non-Steroidal Anti-Inflammatory Drugs (NSAID) which contains paracetamol and ibuprofen. Combiflam helps in the treatment of inflammations and resulting conditions.

Nature of Combiflam Tablet	Non-steroidal Anti- inflammatory drugs
Composition	Ibuprofen and Paracetamol
Uses	Fever, Toothache, Cold , Stiff neck, Migraine, Pain, blood disorder and breathing problem should avoid the medicine.
Precautions:	Patient with history of heart diseases or failure, asthma attack
Side-effects:	Rash, Anemia, Nausea, Mouth ulcer

The Combiflam is a not an over-the-counter medicine and a doctor should be consulted before the buying and consuming the medicine. The drugs should not be given to children below 6 months. Paracetamol and Ibuprofen are the main active ingredients of the Combiflam tablet. It works by controlling the hormones responsible for inflammation. Thus, the tablet of Combiflam is prescribed for arthritis, toothache, back ache, menstrual cramps, small injuries, headache, etc.

Uses and Benefits of Combiflam:

The Combiflam carries anti-inflammatory property which helps in relieving the inflammation and associated conditions. Acetaminophen present in the Combiflam helps in the treatment of fever.

Major uses of the combiflam medicine are listed below:

Fever: Tablet of Combiflam provides temporary relief from pain and fever, but it doesn’t treat the underlying cause. Hence, a doctor should be consulted to diagnose the cause.
Pain (Mild to moderate): The tablet of Combiflam is used to treat pain which may be associated with toothache, body pain, etc. The pain may vary between mild and moderate.
Menstrual Cramps: The Combiflam medicine is found to be effective in case of menstrual cramps and associated abdominal conditions in women.
Osteoarthritis: Combiflam Tablet is used to treat the symptoms of Osteoarthritis which include tender and swollen joints.
Rheumatoid Arthritis: Combiflam is used to treat symptoms associated with Rheumatoid arthritis which include pain, stiffness and swelling of joints.
Gout: Combiflam Tablet assists in relieving swelling and pain associated with gout.

The Combiflam Tablet only aids in relieving symptoms and not the underlying cause. Hence, a doctor should be consulted and proper course of treatment should be taken as per the clinical condition.

Side effects of Combiflam:

Combiflam are very useful for treatment and improvement of above-mentioned conditions, but there are certain side effects that it carries. It is important to know the side effects before the consumption.

The side effects of combiflam do not occur usually, however if they occur, here is a list of condition that an individual might experience:

Diarrhea	Decreased urine output
Abdominal pain	Drowsiness
Constipation	Blood in vomit
Epigastric pain	Buzzing in the ears
Heartburn	Fluctuations in blood count
Nausea	Fatigue
Vomiting	Yellow colored skin or eyes
Swelling	Cloudy or bloody urine
Rash	Edema
Itching	Breathlessness
Liver damage	Steven-Johnson syndrome
Kidney damage	Anaphylactic reaction
Anemia	Mouth ulcer
Appetite loss

Common Dosage of Combiflam:

There is no specific instruction regarding the dosage of Combiflam. Combiflam dosage depends on the severity of the condition and the medical history of the patient. If the condition is severe, the dosage prescribed is usually high. Other than that, it is advisable to never exceed the dosage without the instruction of a medical professional, as it might be very dangerous. In case of a missed dose of Combiflam, consume the medicine as soon as you remember. However, if the time of the missed dose is overlapping with the next dose; it is advisable to skip the missed dose and continue with the usual schedule. In case of overdose, a doctor should be consulted as soon as possible.

The Combiflam Tablet is available in the following variants:

Paracetamol- 325 mg
Ibuprofen- 400mg

Price of Combiflam In India:

Combifam Tablet Price	INR 12.37 per strip of 15 tablets
Combifam Tablet Price	INR 31.8 (strip of 20 tablets)
Combiflam suspension Price	INR 27.78 (Bottle of 60ml)
Combiflam icy hot pain relief gel Price	INR 46 (Tube of 15gm)
Combiflam icy hot pain relief gel Price	INR 89 (Tube of 30gm)
Combiflam icy hot pain relief spray Price	INR 159 (Packet of 55gm)
Combiflam icy hot pain relief spray Price	INR 105 (Packet of 35gm)

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Composition and Nature of Combiflam:

Combiflam is made up of a combination of drugs. These drugs help in inhibiting the hormones and enzymes responsible for inflammations and pain.

The composition of the Combiflam Tablet include the following:

Ibuprofen- The drug belongs to the class of non steroidal anti-inflammatory drug. It helps in the treatment of inflammations and pain due to migraines, rheumatoid arthritis, menstrual cramps, Fever etc.
Paracetamol- Paracetamol belongs to the class of acetaminophen, APAP. It is used in the treatment of fever and moderate pain. The medicine is also combined with other drugs as well as to provide multiple effects.

How to use Combiflam?

While using the Combiflam, following things should be kept in mind:

Combiflam should be taken with food.
Combiflam dosage should be kept strictly to the doctor’s prescription.
Alcohol should be avoided while consuming Combiflam.
Check for ingredients before using the medicine to avoid any kind of complications.
Ongoing drugs should be discussed with medical practitioner beforehand to avoid risk of interaction.

How does Combiflam Tablet work?

Combiflam Tablet works by blocking the synthesis of Cyclooxygenase (or COX2). It is an enzyme which is responsible for the stimulation of prostaglandins in the body. The release of prostaglandins results in inflammation, swelling, and pain of the joints.
By blocking the production of cyclooxygenase (COX2), synthesis of prostaglandins is also inhibited. Therefore, conditions such as migraine, osteoarthritis, joint swellings, rheumatoid arthritis, inflammation, menstrual pain, postoperative pain, and fever are alleviated using this medicine.
The drug blocks the production of all the enzymes or components that stimulate the process of inflammation such as free radicals, proteolytic enzymes, cyclooxygenase, histamine and prostaglandin. It also helps to relieve acute pain due to menstrual cramps, stiff neck, and osteoarthritis. Combiflam Tablet works on the brain centers responsible for maintaining body temperature and reduce the increased body temperature.The Combiflam accelerates the pain threshold and elevates the blood flow across the skin, sweating and heat loss.
The effect of Combiflam can be seen in half an hour to an hour. While, it lasts for an average duration of 4-6 hours.

What Combiflam is prescribed for?

Combiflam Tablet is prescribed for following medical conditions:

Fever	Osteoarthritis
Cold	Rheumatoid arthritis
Toothache	Spondylitis
Body pain (ear, back, joints)	Gout
Headache	Sprain
Muscular pain	Cervical pain
Menstrual cramps	Stiff neck
Neuropathic pain	Migraine
Dental abscess

Precautions and Warning – When to avoid Combiflam?

It is not advisable to take Combiflam Tablet

If an individual is allergic to tablet of Combiflam or any of its ingredients.
If an individual is allergic to non-steroidal anti-inflammatory drugs (NSAID) such as Diclofenac, Aspirin, etc.
If there was an asthma attack, face swelling, itchy red bumps on the skin, bleeding in stomach, or nose irritation.
If there is any history of stomach bleeding or stomach/ intestine ulcers.
If an individual has liver or kidney disease.
If an individual has suffered heart failure, heart disease or a stroke.
If an individual is suffering from any blood disorder or porphyria.
If an individual is suffering from any breathing problems.

How to store Combiflam?

Combiflam should be stored away from light and heat. The recommended storage temperature is 25°C.

Substitutes of Combiflam:

Combiflam might not be suitable for every person due to the composition or the medical condition of the person. In that case, the person should switch to the substitute of the Combiflam. Substitutes of Combiflam with the same ingredients but varying composition are listed below. The medicine should be consumed only after consulting a medical professional.

Fenmol 400 mg/325 mg Tablet- Rekvina Laboratories Ltd
Zupar 400 mg/325 mg Captab- Glaxo SmithKline Pharmaceuticals Ltd
Ibunij 400 Mg/325 Mg Tablet- Sunij Pharma Pvt Ltd
Lupiflam 400 mg/325 mg Tablet- Lupin Ltd
Ibupar 400 mg/325 mg Tablet- Troikaa Pharmaceuticals Ltd
Ibudex 400 mg/325 mg Tablet- Wockhardt Ltd
Pyremol Plus Ib 400 Mg/325 Mg Tablet- Alembic Pharmaceuticals Ltd
Lupiflam M Tablet- Lupin Ltd

Combiflam Interactions:

Taking more than one medicine or mixing the medicine with specific foods might put a person at risk of drug interaction. An individual should check all the details before consuming Combiflam to avoid any kind of interaction.

Disease in which Combiflam Tablet Should be Avoided:

The Combiflam Tablet might affect the present disease or conditions and intensify it. Thereby, it is suggested to share all the medical history with a doctor.

Some of the diseases and conditions that Combiflam is known to intensify is mentioned below:

Asthma (Major) – Combiflam should be avoided in the case of NSAID-sensitive asthma. If there existed any trace of NSAID-sensitive asthma in the past, a doctor must be informed about it. It is advisable to go for substitute of Combiflam, after consulting doctor.
Fluid retention and Edema (Major)- If an individual has the concern of fluid retention and edema, one must consult a medical professional before the consumption of the medicine. Also, during the course of medicine, heart conditions and blood pressure should be monitored on the regular basis.
Skin rash (Major) – There are cases of Combiflam causing skin allergies such as hives, rashes, fever or other allergic reaction without any prior warning. If an individual experience any of this kind of skin allergy, a doctor should be consulted as soon as possible, as the condition requires immediate medical intervention.
Liver disease- The medicine should be avoided by patients suffering from any kind of liver disease as the medicine may intensify the effects. It is recommended to monitor the liver functions while consuming the Combiflam. It is advisable to go for appropriate alternative depending on the clinical condition.
Chronic Malnutrition- The medicine should be avoided or used with extreme caution in patients going through malnourished, as it may affect the condition adversely.

Based on clinical condition, an individual should go for dose adjustment or an appropriate alternative.

Avoid tablet of Combiflam Consumption With Alcohol:

When the medicine interacts with alcohol, it can lead to conditions such as stomach bleeding, coffee colored or dried blood in stools or cough. If an individual consumes alcohol in the course of medicine, it should be reported to a doctor immediately.

Avoid tablet of Combiflam before Lab test:

5-HIAA Urine Test (Moderate): After consuming Combiflam, an individual should avoid taking 5-HIAA Urine Test, as it may give a false-positive result for this test. Thus, it is advisable to share details of all the medicine being consumed and present conditions before undergoing the lab tests.

Combiflam should not be taken with:

Sometimes, taking more than two medicines at a time can nullify the effect of either medicines or react together to result in some adverse condition that might pose a serious risk to health. It is suggested to read instruction about the compounds and salts available in the medicine and respective results of the interaction. Also, a medical professional should also be aware of the details of ongoing medicines, if any, before prescribing combiflam.

Some of the medicines that should be avoided while consuming tablet of Combiflam are listed below:

Methotrexate (Major): Combiflam when taken along with Methotrexate can result in the liver injury, bleeding and breathing problem. The detail of combiflam should be shared with a medical professional beforehand. Dosage should be adjusted based on the requirement. Also, kidney functions and blood cell count should be monitored closely during the course of the medicine.
Corticosteroids (Moderate): The combination of both the medicines can increase the risk of gastrointestinal bleeding. A doctor should be informed about consumption of Corticosteroids beforehand. An alternative to Combiflam should be considered after consulting a medical professional.
Aspirin (Major): Combiflam when taken along with Aspirin may nullify or reduce the effect of Aspirin. Apart from that, there is a risk of bleeding. In case, an individual experience symptoms such as blood in stools, gastrointestinal bleeding and abdominal pain, a doctor should be consulted without any delay as the condition require immediate medical intervention. In such circumstance, an alternative of the medicine should be considered.
Antihypertensive (Moderate): Combiflam when taken with antihypertensive such as Ramipril and Furosemide elevate the risk of kidney damage. In such circumstances, kidney functions should be monitored on the regular basis.

The interaction is usually seen in elderly people. The doses should be adjusted according to the clinical condition or an alternative should be selected, if required.

Suspension form of Combiflam:

combiflam is available in suspension form as well. It acts as non-steroidal anti-inflammatory drugs.
The suspension form of combiflam can be used by person who is above 6 months.
The precautions and warnings should remain same in either form of Combiflam.

Mentioned below is the list of suspension form that can be used as substitutes of the medicine:

Adiflam Plus Suspension
Artigesic 100 mg/162.5 mg Suspension
Artigesic 100 mg/162.5 mg Suspension
Bruace Suspension
Bren Plus 100 mg/162.5 mg Suspension
Dolomec Suspension
Ibucon Plus Suspension
Ibugesic Plus Suspension
Flexon Suspension
Imol Suspension
Ibu P 100 Mg/162.5 Mg Suspension
Simultin P 100 Mg/162.5 Mg Suspension
P K 100MG/162.5MG Suspension
Ibutop 100 Mg/162.5 Mg Suspension
Ibukind Plus 100 mg/162.5 mg Suspension

Combiflam Variants:

The following are the variants of the medicine:

Combiflam tablet
Combiflam syrup
Combiflam gel
Combiflam pain relief spray

FAQs Answered:

1) How long I need to wait to see the effects of Combiflam tablet?

Ans: Combiflam tablet starts showing its effect within 30 minutes of consumption.

2) What is the duration of the effect of Combiflam?

Ans: Combiflam shows its effect till 6 hours from the consumption.

3) Is Combiflam safe to use during pregnancy?

Ans: The use of Combiflam tablet is not recommended for pregnant women unless very much necessary. All the risks and benefits should be shared with the medical professional beforehand.

4) Is Combiflam tablet, safe to use while breastfeeding?

Ans: Combiflam tablet is not recommended for breastfeeding women, if not necessary. The related risks and benefits should be discussed beforehand to avoid any further complications.

5) Is it safe to drive after consuming Combiflam?

Ans: Combiflam can make a person feel dizzy, sleepy or drowsy. Thus, it is suggested not drive after the consumption of Combiflam.

6) What if I consume an expired Combiflam?

Ans: A single dose of expired Combiflam might not produce any adverse effect on health. However, it is recommended to consult a medical professional to be on safe side.

7) What will be the consequence of an overdose of Combiflam tablet?

Ans: In the case of an overdose of Combiflam tablet, an individual should immediately consult a doctor .

8) Is Combiflam addictive?

Ans: No, Combiflam Tablet is not addictive.

9) Is there any food item to be avoided while consuming Combiflam tablet?

Ans: No, there is no specific list of food items to be avoided while consumption of Combiflam Tablet.

10) How to store Combiflam Tablet?

Ans: The Combiflam tablet should be stored at 25°c and should be kept away from heat and light.

11) What is Combiflam Tablet used to treat?

Ans: Combiflam tablet is prescribed for following medical conditions:

Pain
Fever
Cold
Dental abscess
Headache
Muscle pain
Joint pain

12) What are the side effects of Combiflam Tablet?

Ans: Side effects of Combiflam tablet vary from one individual to another, and are dependent on various factors such as ongoing drugs, clinical condition, lifestyle, etc. Some of the commonly reported side effects include the following:

Nausea
Vomiting
Fatigue
Abdominal pain
Mouth ulcers
Sever heartburn

13) What precautions should I follow while taking Combiflam?

Ans: Before taking Combiflam, keep the following things in mind:

Kidney: Patients suffering from kidney disease should use this medicine with caution. Dose adjustments would be needed. Long term use of this medicine may harm the kidney function.
Liver disease: Patients suffering from liver disease should use this medicine with care. Dose adjustments would be needed.
Pregnancy: Combiflam can be harmful during pregnancy. One should only take this medicine after consulting the doctor.
Alcohol: One should avoid taking the suspension form of the medicine as it may cause extreme drowsiness and increase the risk of liver damage.
Food: Do not take this medicine on an empty stomach as it may cause lose motions.

14) What other information I should know regarding Combiflam?

Ans: Keep all the appointments with your doctor and the laboratory. The doctor may order certain lab tests to check how your body is responding to Combiflam. If your symptoms are not yet cured, then speak to your doctor immediately in this regard.

Do not let anyone else take the medicine. Apart from this, always keep a list of prescription and non-prescription medicines you are taking and other products such as vitamins, minerals and other supplements.

15) Is it safe to take Combiflam on an empty stomach?

Ans: Medicines like Ibuprofen, Combiflam and other NSAIDs can cause irritation in the stomach lining. Therefore, it is always suggested to take it along with food or milk.

16) Can I stop using Combiflam when the pain is relieved?

Ans: Use Combiflam as told by the doctor. If your symptoms have been cured then you can stop this medicine, but only under medical supervision.

18.In what conditions the medicine should not be used?

Ans: Combiflam should not be used in the following situations:

Allergy: If you are allergic to Combiflam or any other NSAID drug, then do not use Combiflam.
Asthma: If you had a history of asthma, rhinitis and uticaria, then avoid taking the Combiflam.
Coronary Artery Bypass Surgery (CABG): If you had a recent heart surgery, therefore it is not advised to use Combiflam Tablet.
Gastro-intestinal bleeding: Patients suffering from peptic ulcer and any other gastrointestinal disorder should not use Combiflam Tablet.

20. Is Combiflam safe for children?

Ans: Combiflam contains ibuprofen that has been used from a long time now. Infants falling in the weight bracket, should not be recommended with Combiflam. While, the older children will not face issue if they take the Combiflam adhering to the dosage.

21. How and when to give Combiflam?

Ans: Combiflam should be given along with food and should be strictly taken as per the prescription. One should avoid taking alcohol along with the Combiflam.

22.What are the general warnings related to Combiflam?

Ans: Patients should take extreme care if they are suffering from following the following medical conditions:

Malnutrition: The risk of serious side effects cannot be avoided. Based on the physical examination, appropriate adjustments in dosage and prescription of another medicine can be provided by the doctor.
Gastro-intestinal bleeding: Long term use of the Combiflam may trigger gastrointestinal bleeding and perforation, especially among elderly and those with such issues. Dosage adjustments may be required in such cases.
Alcohol: If a person is addicted to alcohol, there are chances of liver damage. In such cases, avoid Combiflam.
Anaemia: An anaemic should used Combiflam with caution as it may harm an individual’s health. In extreme cases, an alternative medicine should be used.
Liver impairment: If a patient is suffering from liver impairment and other disease, he or she should be cautious. A close watch on liver function and Combiflam dosages may be advised.

23. What should I know about the dosage of Combiflam?

Ans: The dosage of the Combiflam is based on the following factors:

Body weight and age of the patient.
Health condition of the patient
Severity of the issue.
History of drug reactions and allergies.

Based on the above dosage of the tablet:

Adults: Maximum 4 gms daily dosage of 0.5-1gm to 4-6 hours is required.
Children

Upto 1 year: 60-120 mg 4-6 hours daily maximum of 4 doses in a day.
1-5 years: 120-250mg 4-6 hours maximum of 4 doses in a day.
6-12 years: 250-500mg 4-6 hours maximum of 4 doses in a day.

24. How does Combiflam Tablet works?

Ans: The Combiflam works by working on the brain that triggers pain and risen body temperature.

It restricts the effects of enzymes called cyclo-oxygenase (COX).
The enzymes help the body in producing prostaglandins which are responsible for causing pain and redness at the site of injury in the body.
Reduction of COX enzymes results in the lower production of prostaglandins.
Since production of prostaglandins is restricted, it eases the pain and increases blood flow across the skin that causes heat loss and sweating.
The body temperature is regulated to lower it sufficiently with reduced pain and swelling.

25. What are the tips to keep in mind while taking Combiflam?

Ans: During the course of Combiflam, adhere to the following tips:

Drink plenty amount of water to reduce the risk of stomach irritation or indigestion.
Inform your doctor if you are planning pregnancy because the medicine may make it difficult to become pregnant.
Inform the doctor if you have a history of gastric upset, in such cases take the tablet with food or milk to avoid stomach upset.

Though there are risks associated with the Combiflam, but it is a safe drug if taken in medical supervision.

26) What is Combiflam used for?

Ans: Combiflam is a Non-steroidal anti-inflammatory drug which also has analgesic and antipyretic properties. Combiflam is generally prescribed to alleviate menstrual and arthritic pain. The medicine may also be prescribed to alleviate symptoms such as toothache, back pain, muscle pain, and fever.

27) Why is Combiflam harmful?

Ans: The medicine is harmful because its prolonged use can cause severe liver damage.

28) Is Combiflam banned in India?

Ans: No, the medicine is not banned in India and is readily available on all medical stores.

29) Can I use Combiflam for fever?

Ans: Yes, Combiflam has antipyretic properties and it can be used to alleviate fever.

30) Is prolonged use of Combiflam harmful?

Ans: Yes, prolonged use of Combiflam is harmful as it may cause liver damage.

Combiflam Tablet: Uses, Side Effects, Dosage, Composition & Price