Clexane 40 MG Injection: Uses, Side Effects, Composition & Dosages

Clexane 40 MG Injection: Uses, Side Effects, Composition & Dosages post thumbnail image

Those who have ever suffered or are suffering from pulmonary embolism or deep vein thrombosis know very well about Clexane 40 Mg Injection. Actually, this injection is an anticoagulant. It helps in the prevention of the formation of blood clots. It is used with warfarin to treat blood clots. Mostly it is given by the doctors when the patient is hospitalized. Clexane is mostly used in combination therapy. 

Uses & Benefits of Clexane:

The uses of Clexane 40 Injection are many and not just one. It is mostly used for the treatment of the following diseases:

  • Deep Vein Thrombosis (DVT)
  • Prophylaxis for Angina
  • Prophylaxis for DVT
  • DVT Prophylaxis after surgery

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Side Effects of Clexane:

The side effects of Clexane 40 MG Injection are many. Some of the side effects, which rarely appear, can be of serious nature. Let us enlist some of the major side effects of Clexane:

  • Fever
  • Irritability
  • Bleeding at the site of injection
  • Bleeding Gums
  • Increase in the menstrual flow speed
  • Convulsions
  • Blood clots under the skin
  • Bleeding Gums
  • Diarrhea
  • Fast Heartbeats
  • Dizziness
  • Confusion
  • Fatigue
  • Low platelet count
  • Trouble in walking or speaking.
  • Slow loss of control on the legs or hands grip.
  • Black Stools
  • Abdominal pain
  • Redness of arms and legs
  • Chest pain
  • Allergic Reactions

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Common Dosages of Clexane:

There is no fixed dosage of Clexane 40 MG Injection for each and every patient. For patients with venous thromboembolism, the dosage is 2000 – 4000 IU daily.  For the treatment of deep vein thrombosis 100 IU (per Kg body weight), twice a day. After hemodialysis, it is given in a quantity of 50 IU per kg (body weight) twice a day. So in all the circumstances, the doctor’s discretion and the prescription are considered final. 

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Composition and Nature of Clexane:

The major component of the Clexane is Enoxaparin and it is being manufactured by Sanofi India Ltd. In India. 

How Clexane 40 MG Injection works?

Actually, the composition of Clexane 40 MG Injection is such that it stops or prevents clotting factors. It is an anticoagulant that does not allow the formation of blood clots of any kind. Clexane blocks the formation of blood clotting proteins. 

Precautions and Warning – When to avoid Clexane?

There are various precautions for Clexane 40 MG Injection usage. Clexane must not be clearly used when:

  • Someone has an allergy to any of its content
  • If there are bleeding disorders.
  • If a woman is pregnant.
  • If there is impaired liver or kidney function.
  • If a person had gone through the surgical procedure of any kind.
  • Someone who had or has Heparin-Induces Thrombocytopenia.

Note: If there is bleeding from the nose, wounds, or gums for more than 15 min. Or if the blood appears while vomiting, or in urine or stool, it is highly advisable that you need to see a doctor immediately for such symptoms. 

Substitutes for Clexane:

There are various known and famous substitutes for Clexane medicine. These substitutes have the exact same composition as that of Clexane 40 MG Injection. Some of them are:

  • Suparin (Orchid Chemicals and Pharmaceuticals)
  • Oxprin (Micro Labs Ltd.)
  • Enoxacare (Ipca Lab)
  • Angionox (Zydus Cadila)
  • Lonopin (Bharat Serums and Vaccines)

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Clexane 40 MG Injection Interactions with Other Drugs:

All the medicines interact differently with different drugs. Moreover, the interaction varies from person to person. It is always better to find all the interactions of medicine before its consumption. Disclose all of your medical histories, information about medicines/herbal supplements/vitamin supplements you are taking before the doctor. This may save you from all the possible side effects of any medicine. The known interactions of Clexane 40 MG Injection:

Interactions with Medicines: 

  • Angiotensin
  • Nonsteroidal anti-inflammatory drugs
  • Escitalopram
  • Roxifiban
  • Tirofiban
  • Eptifibatide
  • Clopidogrel
  • Ticlopidine

Interactions with Diseases:

  • Liver diseases: The person having liver injury must not consume Clexane because it increases the risk of bleeding for them.
  • Bleeding disorders: The same is with patients with bleeding disorders. Patients with hemophilia and bleeding in the gastrointestinal tract must nor take Clexane 40 MG Injection, as it increases the risk of heavy bleeding.


1) When does Clexane 40 MG Injection start to show its effect on the patient’s body?

Ans: The effect of this injection can be felt in an hour. At max, the effects of Clexane 40 MG Injection can be observed in 3-4 hours of its application. 

2) How long does the effect of Clexane remain on the body?

Ans: The average duration for which the effect of the Clexane 40 MG Injection remains on the body is about 12 hours. 

3) Is it safe to take Clexane 40 MG Injection while consuming alcohol?

Ans: Well, the contents of Clexane 40 MG Injection are not known to cause any harmful side effects when consumed with alcohol. But in all the cases, the doctor’s discretion and the prescription must be considered final. 

4) Is the nature of Clexane addictive?

Ans: The nature of Clexane 40 MG Injection has not been found to be addictive by any of its users or government organization. You must remain tension-free for this aspect. 

5) Is Clexane 40 MG Injection recommended for pregnant ladies?

Ans: No, Clexane 40 is not recommended to be taken by pregnant ladies, unless utterly necessary. In all cases, the doctor’s discretion and the prescription must be considered final. 

6) Is Clexane safe while breastfeeding?

Ans: There are no established studies to show if it is safe or not for breastfeeding mothers or not. But it is recommended that this injection must be taken only if there is a high requirement of the same. But in all the cases, the doctor’s discretion and the prescription must be considered final. 

7) Can the regularity of Clexane 40 be altered according to one needs? Or if it can be stopped immediately?

Ans: No, every medicine needs to be taken after the doctor’s advice only. An abrupt end to its consumption may have some rebound effect on the body. So to avoid the possible side effects, Clexane must be taken as prescribed by the doctor. 

8) Where is the injection of Clexane usually given on the body?

Ans: The injection of Clexane is given mostly under the skin of the stomach (abdomen). 

9) Is it safe to drive or work on heavy machinery after taking this Injection?

Ans: As always suggested, if one sees a negative alteration in the condition of the body like feeling dizzy, drowsy, headache, hypotension, etc. it is highly advisable that one must not drive or work on heavy machinery after that. 

10) Are there serious warnings against taking Clexane for liver or kidney patients?

Ans: Yes, Clexane 40 MG Injection may cause some serious side effects to liver and kidney disease patients. One must consult the doctor before taking Clexane.

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