Brufen 400 MG Tablet: Uses, Side Effects, Composition & Dosages

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Brufen 400 MG Tablet, which is commonly known as Ibuprofen is an essential drug that is needed by virtue of its palliative properties in managing any type of disorder associated with pain and inflammation. It is a nonsteroidal anti-inflammatory drug (NSAID) that is most commonly used during fever and pain. It is either administered orally or intravenously. This drug takes effect after an hour. In premature babies, this drug is given to close a patent ductus arteriosus, which, if left untreated may result in congenital heart failure.

Brufen is safe in comparison to other anti-inflammatory nonsteroidal drugs and has fewer side effects, which explains the World Health Organization’s acknowledgment of this drug.

Composition and Nature of Brufen 400 MG Tablet:

Ibuprofen (400 mg) is the active ingredient present in Brufen 400 MG Tablet.

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Uses of Brufen 400 MG Tablet:

Ibuprofen is used to treat the following medical issues:

  • Headache
  • Dental pain
  • Menstrual cramps
  • Muscle pain
  • Arthritis
  • Common cold and flu (works as a pain-reliever)

In short, provides relief from any kind of pain.

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Side Effects of Brufen 400 MG Tablet:

The common and mild side effects of ibuprofen are an upset stomach, nausea, vomiting, heartburn, rash, hard stool, drowsiness, and dizziness. If the side effects persist, the patient must see a doctor. Patients who take Brufen 400 MG Tablet frequently are more likely to suffer heart, liver, and kidney failure later in their lives. It can also aggravate the symptoms of asthma.

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Common Dosage of Brufen 400 MG Tablet:

In the case of Osteoarthritis and Rheumatoid Arthritis, patients (adults) are usually prescribed 400-800 mg of Brufen 400 MG Tablet, to be taken 6-8 hours on a regular basis. Depending on the severity of the condition the dose can be increased to 3200 mg.

Before electroconvulsive therapy 600 mg of this medicine is administered 90 minutes prior to the beginning of the procedure.

In the case of normal headaches, a patient is usually given 400-800 mg of this drug and the frequency of administration depends on the severity of the headache.

In case of general fever and pain (mild to moderate), 200-400 mg of this medicine needs to be taken every 4-6 hours. If it is given intravenously, then the dose should not exceed 800 mg in case of pain and 400 mg in case of fever. The procedure should continue for 30 minutes and must be repeated every 6 hours or so.

In children between the age of 12 months and 6 years, the dose should depend on the bodyweight of the child. In case of fever (5 mg per kg of body weight) this drug is to be given every 6 to 8 hours if the temperature is below 102.5 degrees Fahrenheit. If the temperature is more than 102.5 degrees Fahrenheit, then (10 mg per kg of body weight) this drug needs to be given 6 to 8 hours. The dose should not exceed 40 mg per body weight in children.

For pain 4 mg to 10 mg per kg of ibuprofen should be given to children every 6 to 8 years. The dose should not exceed 40 mg per body weight.

In the case of Rheumatoid Arthritis in children, 20 mg to 40 mg per kg of this medicine should be given 3 to 4 times in the course of a day.

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How Brufen 400 MG Tablet Works?

The medicine works by inhibiting cyclooxygenase-2. As a result, the synthesis of prostaglandins is reduced which in turn decreases inflammation, pain, and fever. It also works on the hypothalamus and accelerates peripheral blood flow, vasodilation, and dissolution of the heat.

Warnings and Precautions When to Avoid Brufen 400 MG Tablet:

Patients should acquaint their doctor with their present medical condition and provide him a complete record of prescribed drugs that they are on currently. Here are some important counseling points that patients must remember:

  • Kidney diseases
  • Liver diseases
  • Asthma
  • Allergy
  • Allergic to aspirin
  • High Blood Pressure
  • Presence of nasal polyps
  • Heart disease
  • Stomach or intestinal problems
  • Ulcers

It is important to drink a lot of water, or as per the instruction of the doctor when one is on Brufen 400 MG Tablet, as dehydration might increase one’s chance of developing heart and kidney disorders at a later stage in life. Patients must monitor the colour of the urine and on noticing anything abnormal the doctor should be consulted. The patient must abstain from alcohol, marijuana, heavy-lifting, or driving while on this drug as it can make one dizzier. One should also avoid tobacco because it might increase the chances of stomach bleeding.

Usually, the doctor would advise against direct exposure to sunlight when on this medicine. Talk to your doctor about this drug if you are pregnant, or are planning to conceive, or are lactating.

Drug Interaction with Brufen 400 MG Tablet:

To reduce the occurrence of drug interaction let your doctor know of all the medicines that you take on a daily basis. Drug interaction can either aggravate the side effects of the drugs or render them ineffective. Brufen 400 MG Tablet is known to interact with Aspirin, Aliskiren, ACE inhibitors, cidofovir, lithium, diuretics, blood-thinners, naproxen, celecoxib, ketorolac, etc.

Substitutes for Brufen 400 MG Tablet:

Here are some of the substitutes of Brufen 400 MG Tablet:

  • Icparil
  • Fenlong
  • Maxofen
  • Flamar
  • Ibuflamar
  • BREN
  • Novigan
  • Bruriff
  • Tricofen
  • Ibutas
  • Ibupal
  • Norswel
  • Tabalon


1) Can I give Brufen 400 MG Tablet to my pet dog?

Ans: You must talk to your veterinarian before giving your dog ibuprofen. Do not give this medicine to your pet without prior consultation, because this can lead to the development of fatal disorders in your four-legged companion- like kidney, liver, and digestive diseases. There are many painkillers available for pets that can treat pain and inflammation.

2) How should I take Brufen 400 during menstrual cramps?

Ans: The patient can take one to two tablets o0f Brufen 400 MG Tablet, depending on the intensity of the pain during the periods. Repeat the drug every 4 to 6 hours. Do not take more than 4 Tablets in the course of a day.

3) Do I need to take Brufen Tablets on an empty stomach?

Ans: No, you should never have Brufen 400 MG Tablet on an empty stomach. Ibuprofen should be taken after a full meal with a glass of water.

4) What are the telling signs of Brufen 400 overdose?

Ans: Vomiting, convulsions, and excessive dizziness are some of the telling signs of this tablet overdose.

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